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VU 0361737 CAS NO.1161205-04-4
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- Min.Order: 100 Gram
- Payment Terms: L/C
- Available Specifications:
≥98.0%(100-500)Gram≥98.0%(1000-5000)Gram
- Product Details
Keywords
- VU 0361737
- N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide;VU 0361737;2-Pyridinecarboxamide, N-(4-chloro-3-methoxyphenyl)-;CID-44191096;ML128
- 1161205-04-4
Quick Details
- ProName: VU 0361737
- CasNo: 1161205-04-4
- Molecular Formula: C13H11CIN2O2
- Appearance: light yellow solid
- Application: CAS:1161205-04-4; small molecule inhi...
- DeliveryTime: 2 months
- PackAge: 100g,500,1kg.....
- Port: shang hai
- ProductionCapacity: 1000 Gram/Month
- Purity: 98%
- Storage: Dry seal
- Transportation: shipping
- LimitNum: 100 Gram
Superiority
We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research.
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Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.
Details
VU 0361737 is a selective positive allosteric modulator (PAM) for mGlu4 receptor with EC50 of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors.
IC50 value: 110 nM (EC50, for rat ), 240 nM (EC50, for human)
Target: mGlu4
in vitro: VU0361737 is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors. [3]
in vivo: VU0361737 shows high in vivo CL in rat, a short half-life (T1/2 20 min), and demonstrates significant brain exposure (brain-to-plasma ratio of 4.1). [3]