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SetmEegenin 1 CAS NO.1227633-49-9
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C
- Available Specifications:
≥98.0%(100-500)Gram≥98.0%(1000-5000)Gram
- Product Details
Keywords
- SetmEegenin 1
- SteMRegenin 1;4-(2-(2-(benzo[b]thiophen-3-yl)-9-isopropyl-9H-purin-6-ylaMino)ethyl)phenol;SR1;SR-1;Phenol, 4-[2-[[2-benzo[b]thien-3-yl-9-(1-Methylethyl)-9H-purin-6-yl]aMino]ethyl]-;etMRegenin 1;Novart
- 1227633-49-9
Quick Details
- ProName: SetmEegenin 1
- CasNo: 1227633-49-9
- Molecular Formula: C24H23N5OS
- Appearance: close to white solid
- Application: CAS：1227633-49-9； SteMRegenin 1;4-(2-...
- DeliveryTime: 3 months
- PackAge: 100g,500g,1kg,25kg
- Port: shang hai
- ProductionCapacity: 100 Gram/Month
- Purity: 98%
- Storage: Dry seal
- Transportation: shipping
- LimitNum: 100 Gram
Superiority
We are committed to provide excellence in researching, manufacturing and drug discovery process.
Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.
Details
StemRegenin 1(SR1) is an antagonist of the aryl hydrocarbon receptor.SR1 is the first small molecule that promotes robust expansion/self-renewal of human CD34+ peripheral blood and cord blood hematopoietic stem cells (HSCs).
IC50 value: 0.12 uM(EC50, 50% increase in percent CD34+)
Target: aryl hydrocarbon receptor
The compound StemRegenin 1 (SR1) is a selective, cell permeable, small molecule that promotes the self-renewal of human hematopoietic stem cells in culture.Culture of HSCs with SR1 led to a 50-fold increase in cells expressing CD34 and a 17-fold increase in cells that retain the ability to engraft immunodeficient mice. SR1 can be potentially used for ex vivo expansion of normal HSCs or leukemic stem/progenitor cells.