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NSC 14613 CAS NO.91396-88-2
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C
- Available Specifications:
≥98.0%(100-500)Gram≥98.0%(1000-5000)Gram
- Product Details
Keywords
- PluriSln 1
- 4-Pyridinecarboxylicacid, 2-phenylhydrazide;plurisln 1;NSC 14613;PluriSIn#1;PluriSln 1, NSC 14613;PluriSIn #1 (NSC 14613);NSC 14613, PluriSln 1;4-Pyridinecarboxylic acid 2-phenylhydrazide PluriSln 1 N
- 91396-88-2
Quick Details
- ProName: NSC 14613
- CasNo: 91396-88-2
- Molecular Formula: C12H11N3O
- Appearance: White crystal
- Application: CAS：91396-88-2； 4-Pyridinecarboxylica...
- DeliveryTime: 2 months
- PackAge: 100g,500g,1kg,25kg
- Port: shang hai
- ProductionCapacity: 1000 Gram/Month
- Purity: 98%
- Storage: Dry seal
- Transportation: shipping
- LimitNum: 100 Gram
Superiority
We are committed to provide excellence in researching, manufacturing and drug discovery process.
Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.
Details
PluriSln 1(NSC 14613) is an inhibitor of stearoyl-coA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism in hPSCs.
IC50 Value:
Target: SCD1
in vitro: Cellular and molecular analyses demonstrated that the most selective compound, PluriSIn #1, induces ER stress, protein synthesis attenuation, and apoptosis in hPSCs. Close examination identified this molecule as an inhibitor of stearoyl-coA desaturase (SCD1), the key enzyme in oleic acid biosynthesis, revealing a unique role for lipid metabolism in hPSCs. PluriSIn #1 was also cytotoxic to mouse blastocysts, indicating that the dependence on oleate is inherent to the pluripotent state. Finally, application of PluriSIn #1 prevented teratoma formation from tumorigenic undifferentiated cells [1].
in vivo: