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Home > Products >  Kartogenin,

Kartogenin, CAS NO.4727-31-5

  • FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
  • Min.Order: 100 Gram
  • Payment Terms: L/C
  • Available Specifications:

    ≥98.0%(100-500)Gram≥98.0%(1000-5000)Gram

  • Product Details

Keywords

  • Kartogenin,
  • 2-[([1,1'-Biphenyl]-4-ylaMino)carbonyl]benzoic Acid;2-[(Biphenyl-4-yl)carbaMoyl]benzoic Acid;4'-Phenylphthalanilic Acid;Kartogenin;KGN;2-([1,1'-biphenyl]-4-ylcarbaMoyl)benzoic acid;4′-Phenyl-phthalan
  • 4727-31-5

Quick Details

  • ProName: Kartogenin,
  • CasNo: 4727-31-5
  • Molecular Formula: C20H15NO3
  • Appearance: white powder
  • Application: CAS:4727-31-5; Small molecule inhibit...
  • DeliveryTime: 3 months
  • PackAge: 100g,500g,1kg,25kg/drum
  • Port: shang hai
  • ProductionCapacity: 1000 Gram/Week
  • Purity: 98%
  • Storage: Dry seal
  • Transportation: shipping
  • LimitNum: 100 Gram

Superiority

We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research.
 
 
 
We are committed to provide excellence in researching, manufacturing and drug discovery process.
 
 
 
Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.

 

Details

Kartogenin(KGN) is a small molecule stimulator of chondrogenesis; promotes chondrocyte differentiation(EC50=100 nM) and binds to filamin A.
IC50 value: 100 nM(EC50, promotes chondrocyte differentiation) [1]
Target: Chondrogenesis stimulator
Kartogenin is a small molecule kartogenin, which promotes chondrocyte differentiation (median effective concentration = 100 nM), shows chondroprotective effects in vitro, and is efficacious in two OA animal models. Kartogenin binds filamin A, disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program [1]. KGN stimulated type-I collagen synthesis of fibroblasts at the mRNA and protein levels in a time-dependent manner, but KGN did not induce expression of α-skeletal muscle actin (α-sma) or matrix metallopeptidase1 (MMP1), MMP9 in vitro [2]. KGN promoted the type-I collagen synthesis of dermal fibroblasts in vitro and in the dermis of mice through activation of the smad4/smad5 pathway.
in vivo: KGN also increased type-I collagen synthesis in the dermis of BALB/C mice [2].

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