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Dimethyloxaloylglycine (DMOG), CAS NO.89464-63-1
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C
- Available Specifications:
≥98.0%(100-500)Gram≥98.0%(1000-5000)Gram
- Product Details
Keywords
- Dimethyloxaloylglycine (DMOG),
- N-(METHOXYOXOACETYL)-GLYCINE METHYL ESTER;DIMETHYLOXALLYL GLYCINE;DIMETHYLOXALYLGLYCINE;DMOG;Dimethyloxaloylglycine;N-[(Methoxycarbonyl)Methyl]oxaMic Acid Methyl Ester;DiMethyloxaloylglycine (DMOG);N-
- 89464-63-1
Quick Details
- ProName: Dimethyloxaloylglycine (DMOG),
- CasNo: 89464-63-1
- Molecular Formula: C6H9NO5
- Appearance: white solid
- Application: CAS：89464-63-1； Bio-material;NONE;Ami...
- DeliveryTime: 4weeks
- PackAge: 100g,500g,1kg,25kg/drum
- Port: shang hai
- ProductionCapacity: 1000 Gram/Month
- Purity: 98%
- Storage: Dry seal
- Transportation: shipping
- LimitNum: 100 Gram
Superiority
We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research.
We are committed to provide excellence in researching, manufacturing and drug discovery process.
Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.
Details
Dimethyloxallyl Glycine(DMOG) is a cell permeable, competitive inhibitor of HIF-PH(HIF-1α prolyl hydroxylase).
IC50 value:
Target: HIF-1α prolyl hydroxylase
The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-1α prolyl hydroxylase (HIF-PH). DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM. DMOG is therefore expected to act as a pro-angiogenic compound, acting via the HIF-1α system.