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Home > Products >  Oclacitinib

Oclacitinib CAS NO.1208319-26-9

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Keywords

  • Oclacitinib
  • 1208319-26-9
  • High purity oclactinib

Quick Details

  • ProName: Oclacitinib
  • CasNo: 1208319-26-9
  • Molecular Formula: C15H23N5O2S
  • Appearance: off white powder
  • Application: Oclacitinib(PF03394197) is a potent an...
  • DeliveryTime: 4weeks
  • PackAge: 100g,500,1kg.....
  • Port: shang hai
  • ProductionCapacity: 50 Kilogram/Year
  • Purity: 98%
  • Storage: refrigerate
  • Transportation: shipping
  • LimitNum: 100 Gram

Superiority

Oclacitinib(PF03394197) is a potent and selective JAKs inhibitor with IC50 of 10-99 nM; not inhibit a panel of 38 non-JAK kinases (IC50 's > 1000 nM).

IC50 value: 10 nM (JAK1) [1]
Target: JAKs
in vitro: Oclacitinib inhibited the function of JAK1-dependent cytokines involved in allergy and inflammation (IL-2, IL-4, IL-6, and IL-13) as well as pruritus (IL-31) at IC50 's ranging from 36 to 249 nm. Oclacitinib had minimal effects on cytokines that did not activate the JAK1 enzyme in cells (erythropoietin, granulocyte/macrophage colony-stimulating factor, IL-12, IL-23; IC50 's > 1000 nm) [1].
in vivo: Dogs were randomized to receive either oclacitinib (0.4-0.6 mg/kg twice daily for 14 days and then once daily for up to 112 days) or an excipient-matched placebo [2].Dogs were randomized to either oclacitinib at 0.4-0.6 mg/kg orally twice daily or an excipient-matched placebo. An enhanced 10 cm visual analog scale (VAS) was used by the owners to assess the severity of pruritus from day 0 to 7 and by veterinarians to assess the severity of dermatitis on days 0 and 7. Dogs could remain on the study for 28 days [3]. 

 

Details

Identification
Name   Oclacitinib
Synonyms   JAKi; PF 03394197; trans-N-Methyl-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-cyclohexanemethanesulfonamide
copyRight
Molecular Structure   CAS # 1208319-26-9, Oclacitinib, JAKi, PF 03394197, trans-N-Methyl-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-cyclohexanemethanesulfonamide
 
Molecular Formula   C15H23N5O2S
Molecular Weight   337.44
CAS Registry Number   1208319-26-9
     
Properties
 
Solubility   Sparingly Soluble (0.034 g/L) (25 ºC), Calc.*
Density   1.316±0.06 g/cm3 (20 ºC 760 Torr), Calc.*
     
* Calculated using Advanced Chemistry Development (ACD/Labs) Software V11.02 (©1994-2013 ACD/Labs)

 

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