China (Mainland)
Premiumsupplier 
Ertugliflozin PF-04971729 CAS NO.1210344-57-2
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C
- Available Specifications:
≥98.0%(100-500)Gram≥98.0%(100-500)Gram
- Product Details
Keywords
- Ertugliflozin
- PF-04971729;Ertugliflozin;Ertugliflozin/PF-04971729;PF-04971729/PF04971729;1,6-Anhydro-1-C-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-5-C-(hydroxymethyl)-beta-L-idopyranose;PF 04971729-00;PF-04971729
- 1210344-57-2
Quick Details
- ProName: Ertugliflozin PF-04971729
- CasNo: 1210344-57-2
- Molecular Formula: C22H25ClO7
- Appearance: White crystal
- Application: CAS：1210344-57-2； PF-04971729;Ertugli...
- DeliveryTime: 2 months
- PackAge: 100g,500,1kg.....
- Port: shang hai
- ProductionCapacity: 100 Metric Ton/Month
- Purity: 98%
- Storage: Dry seal
- Transportation: shipping
- LimitNum: 100 Gram
Superiority
We are committed to provide excellence in researching, manufacturing and drug discovery process.
Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.
Details
PF-04971729(Ertugliflozin) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2(SGLT2).
IC50 value:
Target: SGLT2
PF-04971729 is currently in phase 2 trials for the treatment of diabetes mellitus. Inhibitory effects against the organic cation transporter 2-mediated uptake of [14C]metformin by PF-04971729 also were very weak (IC50 900μM).The disposition of PF-04971729, an orally active selective inhibitor of the sodium-dependent glucose cotransporter 2, was studied after a single 25-mg oral dose of [14C]-PF-04971729 to healthy human subjects. The absorption of PF-04971729 in humans was rapid with a Tmax at ~ 1.0 h. Of the total radioactivity excreted in feces and urine, unchanged PF-04971729 collectively accounted for ~ 35.3% of the dose, suggestive of moderate metabolic elimination in humans.