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ATB 346 CAS NO.1226895-20-0
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C
- Available Specifications:
≥98.0%(100-500)Gram≥98.0%(1000-5000)Gram
- Product Details
Keywords
- ATB 346
- ATB 346;ABT-346;6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 4-(aminothioxomethyl)phenyl ester;6-Methoxy-alpha-methyl-2-naphthaleneacetic acid 4-(aminothioxomethyl)phenyl ester ATB 346;ATB 346 6-Me
- 1226895-20-0
Quick Details
- ProName: ATB 346
- CasNo: 1226895-20-0
- Molecular Formula: C21H19NO3S
- Appearance: white solid
- Application: CAS：1226895-20-0； Small molecule inhi...
- DeliveryTime: 3 months
- PackAge: 100g,500g,1kg,25kg/drum
- Port: shang hai
- ProductionCapacity: 1000 Gram/Week
- Purity: 98%
- Storage: Dry seal
- Transportation: shipping
- LimitNum: 100 Gram
Superiority
We are committed to provide excellence in researching, manufacturing and drug discovery process.
Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.
Details
ATB-346 is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.
IC50 value:
Target: COX-2
ATB-346 suppressed gastric prostaglandin E(2) synthesis as effectively as naproxen, but produced negligible damage in the stomach and intestine, Unlike naproxen and celecoxib, ATB-346 accelerated healing of pre-existing gastric ulcers. In a mouse airpouch model, ATB-346 suppressed cyclooxygenase-2 activity and inhibited leukocyte infiltration more effectively than naproxen. ATB-346 was as effective as naproxen in adjuvant-induced arthritis in rats, with a more rapid onset of activity. Unlike naproxen, ATB-346 did not elevate blood pressure in hypertensive rats [1]. Treatement with ATB-346 exhibited a significantly more rapid and sustained recovery of motor function, achieving greater than double the increase in locomotion score of the naproxen group by the 10th day of treatment. ATB-346 also significantly reduced the severity of inflammation (proinflammatory cytokines, apoptosis of neural tissue, and nitrosative stress) that characterized the secondary effects of SCI [2].