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LY2874455 CAS NO.1254473-64-7
- FOB Price: USD: 1.00-1.00 /Metric Ton Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C
- Available Specifications:
≥98.0%(100-500)Metric Ton≥98.0%(1000-5000)Metric Ton
- Product Details
Keywords
- LY2874455
- LY 2874455;(R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol;4-[(1E)-2-[5-[(1R)-1-(3,5-Dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-1H-pyraz
- 1254473-64-7
Quick Details
- ProName: LY2874455
- CasNo: 1254473-64-7
- Molecular Formula: C21H19Cl2N5O2
- Appearance: White crystal
- Application: CAS：1254473-64-7；LY 2874455;(R,E)-2-(4...
- DeliveryTime: 3 months
- PackAge: 100g,500g,1kg,25kg
- Port: shang hai
- ProductionCapacity: 100 Metric Ton/Week
- Purity: 98%
- Storage: Dry seal
- Transportation: shipping
- LimitNum: 100 Gram
Superiority
We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research.
We are committed to provide excellence in researching, manufacturing and drug discovery process.
Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.
Details
| LY2874455 |
| 生物活性 体外研究 体内研究 |
| 中文名称: | LY2874455 |
| 中文同义词: | 4-[(1E)-2-[5-[(1R)-1-(3,5-二氯-4-吡啶基)乙氧基]-1H-吲唑-3-基]乙烯基]-1H-吡唑-1-乙醇;LY 2874455,4-[(1E)-2-[5-[(1R)-1-(3,5-二氯-4-吡啶基)乙氧基]-1H-吲唑-3-基]乙烯基]-1H-吡唑-1-乙醇 |
| 英文名称: | LY 2874455 |
| 英文同义词: | LY 2874455;(R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol;4-[(1E)-2-[5-[(1R)-1-(3,5-Dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-1H-pyrazole-1-ethanol;LY2874455/LY-2874455;4-[(1E)-2-[5-[(1R)-1-(3,5-Dichloro-4-pyridinyl)ethoxy]-1H-indazol-3-yl]ethenyl]-1H-pyrazole-1-ethanol LY2874455 |
| CAS号: | 1254473-64-7 |
| 分子式: | C21H19Cl2N5O2 |
| 分子量: | 444.31386 |
| EINECS号: | |
| 相关类别: | 蛋白酪氨酸激酶;小分子抑制剂;Inhibitors;小分子抑制剂，天然产物 |
| Mol文件: | 1254473-64-7.mol |
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| LY2874455 性质 |
| 密度 | 1.44 |
| LY2874455 用途与合成方法 |
| 生物活性 | LY2874455是一个泛FGFR的抑制剂，对FGFR1，FGFR2, FGFR3, 和FGFR4的IC50值分别为2.8 nM, 2.6 nM, 6.4 nM,以及6 nM。并且也能抑制VEGFR2的活性，IC50为7 nM。Phase 1。 |
| 体外研究 | 在RT-112细胞，HUVECs，KATO-III 细胞，和SNU-16细胞，LY2874455抑制FGF/FGFR介导的信号活性。LY2874455在KMS-11，OPM-2，SNU-16 和KATO-III细胞中表现出FGFR依赖性抗增殖作用。 |
| 体内研究 | 在小鼠心脏组织中，LY2874455对FGF诱导的Erk磷酸化表现出有效的抑制作用， TED50 和 TED90 值分别为1.3 和 3.2 mg/kg。在负荷RT-112，OPM-2 (DSMZ)，SNU-16，或NCI-H460异种移植物的小鼠体内，LY2874455 (3 mg/kg p.o.)剂量依赖性抑制肿瘤生长。 |