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NLG919 CAS NO.1402836-58-1
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C
- Available Specifications:
≥98.0%(100-500)Gram≥98.0%(1000-5000)Gram
- Product Details
Keywords
- NLG919
- NLG919;5H-Imidazo[5,1-a]isoindole-5-ethanol, α-cyclohexyl-;1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol NLG919;NLG919 1-CYCLOHEXYL-2-(5H-IMIDAZO[5,1-A]ISOINDOL-5-YL)ETHANOL;alpha-Cyclohexyl
- 1402836-58-1
Quick Details
- ProName: NLG919
- CasNo: 1402836-58-1
- Molecular Formula: C18H22N2O
- Appearance: off white powder
- Application: CAS：1402836-58-1； NLG919;5H-Imidazo[5...
- DeliveryTime: 2 months
- PackAge: 100g,500,1kg.....
- Port: shang hai
- ProductionCapacity: 100 Metric Ton/Month
- Purity: 98%
- Storage: Dry seal
- Transportation: shipping
- LimitNum: 100 Gram
Superiority
We are committed to provide excellence in researching, manufacturing and drug discovery process.
Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.
Details
NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM.
IC50 value: 7 nM/75 nM(Ki/EC50)
Target: indoleamine-(2,3)-dioxygenase inhibitor
NLG919 potently blocks IDO-induced T-cell suppression and restored robust T-cell responses with ED50 of 80 nM. Similarly, using IDO-expressing mouse DCs from tumor-draining lymph nodes, NLG919 abrogated IDO-induced suppression of antigen-specific T cells (OT-I) in vitro, with ED50 of 120 nM. In mice, a single oral administration of NLG919 reduces the concentration of plasma and tissue Kyn by ~ 50%. In mice bearing B16F10 tumors, NLG919 markedly enhances the antitumor responses of naive, resting pmel-1 cells to vaccination with cognate hgp100 peptide plus CpG-1826 in IFA.