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WHI-P180, CAS NO.211555-08-7
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C
- Available Specifications:
≥98.0%(100-500)Gram≥98.0%(1000-5000)Gram
- Product Details
Keywords
- WHI-P180,
- Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-;3-[(6,7-Dimethoxy-4-quinazolinyl)amino]phenol;Janex 3;3-(6,7-dimethoxyquinazolin-4-ylamino)phenol
- 211555-08-7
Quick Details
- ProName: WHI-P180,
- CasNo: 211555-08-7
- Molecular Formula: C16H15N3O3
- Appearance: White crystal
- Application: CAS：211555-08-7； Small molecule inhib...
- DeliveryTime: 3 months
- PackAge: 100g,500g,1kg,25kg/drum
- Port: shang hai
- ProductionCapacity: 1000 Gram/Week
- Purity: 98%
- Storage: Dry seal
- Transportation: shipping
- LimitNum: 100 Gram
Superiority
Details
WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
IC50 Value: 1 uM (Cdk2); 4 uM (EGFR)
Target: EGFR; CDK2
in vitro: WHI-P180 moderately inhibited ABCG2 function, exhibiting weak phototoxicity [1].
in vivo: The elimination half-life of WHI-P180 in CD-1 mice (BALB/ c mice) following i.v., i.p., or p.o. administration was less than 10 min. Systemic clearance of WHI-P180 was 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibited IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis [2].