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Tenovin-1 CAS NO.380315-80-0
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- Min.Order: 100 Gram
- Payment Terms: L/C
- Available Specifications:
≥98.0%(100-500)Gram≥98.0%(1000-5000)Gram
- Product Details
Keywords
- Tenovin-1
- TENOVIN-1;N-[[[4-(Acetylamino)phenyl]amino]thioxomethyl]-4-(1,1-dimethylethyl)benzamide;N-[(4-acetaMidophenyl)carbaMothioyl]-4-tert-butylbenzaMide;Benzamide, N-[[[4-(acetylamino)phenyl]amino]thioxomet
- 380315-80-0
Quick Details
- ProName: Tenovin-1
- CasNo: 380315-80-0
- Molecular Formula: C20H23N3O2S
- Appearance: White crystal
- Application: CAS：380315-80-0； TENOVIN-1;N-[[[4-(Ac...
- DeliveryTime: 3 months
- PackAge: 100g,500,1kg.....
- Port: shang hai
- ProductionCapacity: 1000 Metric Ton/Month
- Purity: 98%
- Storage: Dry seal
- Transportation: shipping
- LimitNum: 100 Gram
Superiority
We are committed to provide excellence in researching, manufacturing and drug discovery process.
Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.
Details
Tenovin-1 is a inhibitor of SIRT1 and SIRT2; activator of p21 and p53.
IC50 Value:
Target: Sirtuin
Tenovin-1 is a compound that belongs to the class of Tenovins, and inhibits SIRT1 and SIRT2. SIRT1 and SIRT2 are protein-deacetylases and are members of the NAD+-dependent class III histone deacetylases. Tenovin-1 has been shown to activate and elevate acetylated p53 levels, induce apoptosis in vitro.
in vitro: Tenovin-1 elevates the amount of p53 protein within 2 hr of treatment. This compound also increases the levels of the p53-downstream target p21CIP/WAF1 protein and mRNA, confirming that tenovin-1 can induce expression from an endogenous p53-dependent promoter [1]. Tenovin-6 inhibits the growth of S. cerevisiae cultures with an IC50 of 30 μM and is more toxic to yeast than the less water-soluble tenovin-1.
in vivo: Initial in vivo experiments indicated that tenovin-1 impairs the growth of BL2-derived tumor xenografts [1].