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RG108, CAS NO.48208-26-0
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C
- Available Specifications:
≥98.0%(100-500)Gram≥98.0%(1000-5000)Gram
- Product Details
Keywords
- RG108,
- DNA Methyltransferase Inhibitor;N-Phthalyl-L-tryptophan;RG108 >98%;RG108/DNA Methyltransferase Inhibitor/N-Phthalyl-L-tryptophan;RG108/RG-108;(S)-3-(Indol-3-yl)-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-
- 48208-26-0
Quick Details
- ProName: RG108,
- CasNo: 48208-26-0
- Molecular Formula: C19H14N2O4
- Appearance: White crystal
- Application: CAS：48208-26-0； Small molecule inhibi...
- DeliveryTime: 3 months
- PackAge: 100g,500g,1kg,25kg/drum
- Port: shang hai
- ProductionCapacity: 1000 Gram/Month
- Purity: 98%
- Storage: Dry seal
- Transportation: shipping
- LimitNum: 100 Gram
Superiority
Details
RG108 is a non-nucleoside inhibitor of DNA methyltransferase with IC50 of 115 nM.
IC50 Value: 115 nM
Target: DNMT
in vitro: RG108 effectively blocks DNA methyltransferases in vitro and does not cause covalent enzyme trapping in human cell lines. Incubation of cells with low micromolar concentrations of RG108 results in significant demethylation of genomic DNA without any detectable toxicity. Intriguingly, RG108 causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences. In another study, the synthesis and in vitro analysis of a biotinylated RG108 conjugate is investigated to evaluate the interactions with DNA methyltransferase enzymes. In a recent study, it is shown RG108 can significantly reduce the DNA methyltransferases activity in SM derived iPS cells as compared to the native SMs.
in vivo: