China (Mainland)
Premiumsupplier 
AR-A014418 CAS NO.487021-52-3
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C
- Available Specifications:
≥98.0%(100-500)Gram≥98.0%(1000-5000)Gram
- Product Details
Keywords
- AR-A014418
- AR-AO 14418;GSK-3β Inhibitor VIII;N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea;N-[(4-Methoxyphenyl)Methyl]-N'-(5-nitro-thiazol-2-yl)urea;AR 0133418;GSK 3B Inhibitor VIII;AR 014418;GSK 3β
- 487021-52-3
Quick Details
- ProName: AR-A014418
- CasNo: 487021-52-3
- Molecular Formula: C12H12N4O4S
- Appearance: close to white solid
- Application: CAS：487021-52-3； AR-AO 14418;GSK-3β I...
- DeliveryTime: 2 months
- PackAge: 100g,500g,1kg,25kg
- Port: shang hai
- ProductionCapacity: 1000 Gram/Month
- Purity: 98%
- Storage: Dry seal
- Transportation: shipping
- LimitNum: 100 Gram
Superiority
We are committed to provide excellence in researching, manufacturing and drug discovery process.
Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.
Details
AR-A014418 is a selective and effective GSK3β inhibitor with an IC50 value of 104 +/- 27 nM; no significant inhibition on 26 other kinases.
IC50 Value: 104 +/- 27 nM [1]
Target: GSK3β
in vitro: AR-A014418 inhibits GSK3 (IC50 = 104 +/- 27 nM), in an ATP-competitive manner (Ki = 38 nM). AR-A014418 does not significantly inhibit cdk2 or cdk5 (IC50 > 100 microM) or 26 other kinases demonstrating high specificity for GSK3 [1]. Colon cancer HCT116 cells were sensitized to apoptosis by co-treatment with reovirus and a GSK-3beta inhibitor, AR-A014418 [2].
in vivo: Injections of AR-A014418reduced immobility time in rats exposed to the forced swim test, a well-established model for antidepressant efficacy. In addition, the specificity of this effect is supported by our finding that AR-A014418 decreased spontaneous as well as amphetamine-induced activity [3]. AR-A014418 coinjection (10 ng/site, it) inhibited nociception induced by glutamate, N-methyl-D-aspartate (NMDA), (±)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (trans-ACPD), tumor necrosis factor-alpha (TNF-α), and interleukin-1beta (IL-1β) by 47 ± 12%, 48 ± 11%, 31 ± 8%, 46 ± 13%, and 44 ± 11%, respectively [4].