China (Mainland)
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LH846 CAS NO.639052-78-1
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C
- Available Specifications:
≥98.0%(100-500)Gram≥98.0%(1000-5000)Gram
- Product Details
Keywords
- LH846
- LH 846;LH846;LH-846;N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide;LH-846 N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide;N-(5-Chloro-6-methyl-2-benzothiazolyl)benzeneacetamide LH 846;L
- 639052-78-1
Quick Details
- ProName: LH846
- CasNo: 639052-78-1
- Molecular Formula: C16H13ClN2OS
- Appearance: white solid
- Application: CAS：639052-78-1； Small molecule inhib...
- DeliveryTime: 3 months
- PackAge: 100g,500g,1kg,25kg/drum
- Port: shang hai
- ProductionCapacity: 1000 Gram/Week
- Purity: 98%
- Storage: Dry seal
- Transportation: shipping
- LimitNum: 100 Gram
Superiority
We are committed to provide excellence in researching, manufacturing and drug discovery process.
Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.
Details
LH846 is a selective inhibitor of CK1δ (IC50 values are 290 nM, 1.3 uM and 2.5 uM for CK1δ, ε and α); displays no inhibitory activity at CK2.
IC50 Value: 290 nM (CK1δ); 1.3 uM (CK1ε); 2.5 uM (CK1α) [1]
Target: CK1
LH846 inhibits CK1δ-dependent phosphorylation and degradation of PER1 protein. Shown to lengthen the circadian period in U2OS cells, with minimal effect on amplitude.
Treatment with LH846 reduced the PER1 mobility shift and PER1 clearance in a dose-dependent manner, indicating that CKIδ-dependent phosphorylation and subsequent degradation of PER1 protein is inhibited by LH846 treatment. Previous genetic studies demonstrated an important role of CKI-dependent phosphorylation of PER protein in period regulation, supporting the period lengthening effect of LH846 through PER1 protein phosphorylation [1].