China (Mainland)
Premiumsupplier 
JW55 CAS NO.664993-53-7
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 100 Gram
- Payment Terms: L/C
- Available Specifications:
≥98.0%(100-500)Gram≥98.0%(1000-5000)Gram
- Product Details
Keywords
- JW55
- JW55;N-(4-((4-(4-Methoxyphenyl)tetrahydro-2H-pyran-4-yl)MethylcarbaMoyl)phenyl)furan-2-carboxaMide;N-[4-[[[[Tetrahydro-4-(4-methoxyphenyl)-2H-pyran-4-yl]methyl]amino]carbonyl]phenyl]-2-furancarboxamid
- 664993-53-7
Quick Details
- ProName: JW55
- CasNo: 664993-53-7
- Molecular Formula: C25H26N2O5
- Appearance: off white powder
- Application: CAS:664993-53-7; Amines;Aromatics;Het...
- DeliveryTime: 3 months
- PackAge: 100g,500g,1kg,25kg
- Port: shang hai
- ProductionCapacity: 1000 Gram/Month
- Purity: 98%
- Storage: Dry seal
- Transportation: shipping
- LimitNum: 100 Gram
Superiority
We are committed to provide excellence in researching, manufacturing and drug discovery process.
Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.
Details
JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2). JW55 decreased auto-PARsylation of TNKS1/2 in vitro with IC50 values of 1.9 uM and 830 nM respectively.
IC50 Value: 1.9 uM (TNKS1); 830 nM (TNKS2) [1]
Target: Tankyrase1/2; PARP
JW 55 efficacy causes stabilization of Axin2 and it increases degradation of β-catenin signaling pathway. JW 55 also decreases canonical Wnt signaling in SW480 and HCT-15 colon carcinoma cell lines. Wnt3a-induced HEK293 cells containing a transiently transfected ST-Luc (SuperTop-luciferase) reporter showed inhibition by JW55 with an IC50 value of 470 nM. In contrast, Shh Light II cells (Gli1-Luc reporter) that were activated with 50% Shh-CM were not inhibited by 10 or 1 μmol/L JW55. Also, TNFαactivated HEK293 cells containing a transiently transfected NF-κB-Luciferase (NF-κB-Luc) plasmid showed no pathway inhibition in the presence of 10 or 1 μmol/L of JW55 [1].