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BX912 CAS NO.702674-56-4
- FOB Price: USD: 1.00-1.00 /Gram Get Latest Price
- Min.Order: 100 Milligram
- Payment Terms: L/C
- Available Specifications:
≥98.0%(0.1-0.5)Gram≥98.0%(1-10)Gram≥98.0%(50-100)Gram
- Product Details
Keywords
- BX912
- 702674-56-4
- 1-PYRROLIDINECARBOXAMIDE, N-[3-[[5-BROMO-4-[[2-(1H-IMIDAZOL-4-YL)ETHYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]-;BX 912;PYRROLIDINE-1-CARBOXYLIC ACID (3-(5-BROMO-4-[2-(1H-IMIDAZOL-4-YL)-ETHYLAMINO]-PYRIMIDI
Quick Details
- ProName: BX912
- CasNo: 702674-56-4
- Molecular Formula: C20H23BrN8O
- Appearance: light yellow solid
- Application: CAS：702674-56-4；1-PYRROLIDINECARBOXAMI...
- DeliveryTime: 4weeks
- PackAge: 100g,500g,1kg,25kg/drum
- Port: shang hai
- ProductionCapacity: 1 Gram/Week
- Purity: 98%
- Storage: Dry seal
- Transportation: shipping
- LimitNum: 100 Milligram
Superiority
We are specialized in custom synthesis, chemical/pharmaceutical/ pesticides outsourcing and contract research.
We are committed to provide excellence in researching, manufacturing and drug discovery process.
Our research team of scientists consists of western-trained Ph.D.s with experience and capabilities in drug R&D methodologies and medicinal chemistry.
Details
| BX-912 |
| 生物活性 体外研究 |
| 中文名称: | BX-912 |
| 中文同义词: | N-[3-[[5-溴-4-[[2-(1H-咪唑-5-基)乙基]氨基]-2-嘧啶基]氨基]苯基]-1-吡咯烷甲酰胺 |
| 英文名称: | BX-912 |
| 英文同义词: | 1-PYRROLIDINECARBOXAMIDE, N-[3-[[5-BROMO-4-[[2-(1H-IMIDAZOL-4-YL)ETHYL]AMINO]-2-PYRIMIDINYL]AMINO]PHENYL]-;BX 912;PYRROLIDINE-1-CARBOXYLIC ACID (3-(5-BROMO-4-[2-(1H-IMIDAZOL-4-YL)-ETHYLAMINO]-PYRIMIDIN-2-YLAMINO)-PHENYL)-AMIDE;N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide;BX912/BX-912;N-(3-(4-(2-(1H-imidazol-5-yl)ethylamino)-5-bromopyrimidin-2-ylamino)phenyl)pyrrolidine-1-carboxamide;BX-912 N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide;N-[3-[[5-Bromo-4-[[2-(1H-imidazol-5-yl)ethyl]amino]-2-pyrimidinyl]amino]phenyl]-1-pyrrolidinecarboxamide BX-912 |
| CAS号: | 702674-56-4 |
| 分子式: | C20H23BrN8O |
| 分子量: | 471.35 |
| EINECS号: | |
| 相关类别: | Inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1).;信号转导通路激酶抑制剂;小分子抑制剂;Inhibitors;小分子抑制剂，天然产物 |
| Mol文件: | 702674-56-4.mol |
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| BX-912 性质 |
| 密度 | 1.596 |
| BX-912 用途与合成方法 |
| 生物活性 | BX-912是一种有效的，特异性的PDK1抑制剂，IC50为12 nM，作用于PKD1比作用于PKA和PKC选择性分别高9和105倍。 |
| 体外研究 | BX912 抑制ChcK1,PKA,c-kit,和KDR，IC50分别为0.83, 0.11, 0.85, 和0.41 μM。BX912 作用于肿瘤细胞，阻断PDK1/Akt信号，在培养中也抑制多种肿瘤细胞的贴壁依赖型生长(比如PC-3细胞)或者诱导凋亡。许多癌细胞系(比如MDA-468乳腺癌)具有提高的Akt活性，在软琼脂中培养的组织对BX912的敏感性比在组织培养塑料上高30多倍, 和PDK1/Akt信号通路的细胞生存一致，这对没有粘附的细胞尤其重要。BX912 有效抑制PDK1酶活, 但是不抑制AKT2活性(IC50>10 μM)。因此, BX-912是PDK1的直接抑制剂。BX912是PDK1 活性的竞争性抑制剂，BX912 结合到PDK1的ATP结合袋中。BX912的氨基嘧啶骨架采用与PDK1激活位点相似的位点。BX912显著提高的含4 N DNA的MDA-468 细胞数, 且使细胞停在 G2/M期。BX912也有效抑制HCT-116细胞生长，按1 μM剂量处理抑制率达96%。BX912有效抑制细胞生长，IC50为0.32μM。 |