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Sofosbuvir intermediate 3 CAS NO.863329-66-2
- FOB Price: USD: 1,000.00-1,000.00 /Kilogram Get Latest Price
- Min.Order: 1 Kilogram
- Payment Terms: T/T
- Available Specifications:
≥98.0%(11-100)Kilogram
- Product Details
Keywords
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- 2'-deoxy-2'-fluoro-2'-C-methyluridine;(2'R)-2'-Deoxy-2'-fluoro-2'-methyluridine;PSI-6206;RO 2433;Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)-;Uridine, 2'-deoxy-2'-fluoro-2'-Methyl-, (2'R)- PSI6206;2
Quick Details
- ProName: Sofosbuvir intermediate 3
- CasNo: 863329-66-2
- Molecular Formula: C10H13FN2O5
- Appearance: off white powder
- Application: Sofosbuvir intermediate 3
- DeliveryTime: 2 months
- PackAge: 100g,500g,1kg,25kg
- Port: shanghai
- ProductionCapacity: 100 Kilogram/Month
- Purity: 98%
- Storage: Dry seal
- Transportation: Dry seal
- LimitNum: 1 Kilogram
Superiority
Details
PSI-6206 (RO2433) is a selective HCV RNA polymerase inhibitor.
IC50 Value: N/A
Target: HCV
PSI-6206 is the unphosphorylated parent compound of triphosphate analog PSI-7409, which is a potent inhibitor of the HCV NS5B RNA dependent RNA polymerase. The monophosphate form of PSI-6206 was shown to be metabolized in primary human hepatocytes to its triphosphate analog PSI-7409. Furthermore, the phosphoramidate prodrug of PSI-6206 monophosphate, PSI-7851, was developed. Alternatively, PSI-6130, an aminated analog of PSI-6206 monophosphate, was also developed. PSI-7409, the triphosphate of PSI-6206 inhibits wild-type and S282T HCV RdRp with Ki values of 0.42 and 22 uM, respectively. PSI-7851, the phosphoramidate of PSI-6206 monophosphate, showed an EC50 value of 1.62 uM for inhibiting HCV RNA replication.